Teratogenic effect of electric mosquito repellents on mouse (Mus musculus) fetuses

Introduction: This study aims to determine the teratogenic effects of electric mosquito repellents on mouse (Mus musculus) fetuses. The repellent used contains active ingredient dimefluthrin 0.566% (4.2 mg/matt) which was inhaled into pregnant mice during organogenesis period 6-15 days gestation. Material and Methods: A total 30 were divided five groups with six repetitions, namely C: Control group (without exposure repellent), T1: exposed for 4 hours/day, T2: 6 T3: 8 hours /day, T4: 10 hours/day. Parameters tested including fetal weight length analyzed using One-Way Anova then continued Duncan test. Live fetuses (%), dead morphological abnormalities (%) Kruskal-Wallis test Mann-Whitney Results: found that there no gross abnormalities, however hemorrhage skin surface. results showed significant differences (p<0.05) in fetus, live fetus (%). Discussion: highest rates death shown T4 treatment (exposed hours/day). Dimefluthrin enters body as a substance forms reactive oxygen species (ROS). Blood vessel cells are ROS have oxidative stress will be damaged even die so blood vessels become brittle break easily.